A Perspective on the Metabolic Potential for Microbial Contributions to Urolithiasis

the diet, host metabolism, and microbial metabolism. The microbial contribution to these compounds is perhaps the most variable given the immense diversity and interindividual variability of microbes inhabiting hosts (microbiome) and the plasticity of host associated microbial communities over time. Recent analyses have found significant associations between antibiotic use and the onset of urolithiasis  as … Leggi tutto

Hyperoxaluria: a gut–kidney axis?

Hyperoxaluria leads to urinary calcium oxalate (CaOx) supersaturation, resulting in the formation and retention of CaOx crystals in renal tissue. CaOx crystals may contribute to the formation of diffuse renal calcifications (nephrocalcinosis) or stones (nephrolithiasis). When the innate renal defense mechanisms are suppressed, injury and progressive inflammation caused by these CaOx crystals, together with secondary … Leggi tutto