Calcium Oxalate Nephrolithiasis and Gut Microbiota: Not just a Gut-Kidney Axis. A Nutritional Perspective

Recent studies have shown that patients with kidney stone disease, and particularlycalcium oxalate nephrolithiasis, exhibit dysbiosis in their fecal and urinary microbiota comparedwith controls. The alterations of microbiota go far beyond the simple presence and representation ofOxalobacter formigenes, a well-known symbiont exhibiting a marked capacity of degrading dietaryoxalate and stimulating oxalate secretion by the gut … Leggi tutto

Dietary Risk Factors for Incident and Recurrent Symptomatic Kidney Stones

… Results: In fully adjusted analyses, lower dietary calcium, potassium, caffeine, phytate, and fluid intake were all associated with a higher odds of an incident symptomatic kidney stone. Among incident stone formers, 73 experienced symptomatic recurrence during a median 4.1 years of followup. Adjusting for body mass index, fluid intake, and energy intake, lower dietary … Leggi tutto

Calcium and Vitamin D Supplementation and Their Association with Kidney Stone Disease: A Narrative Review

Abstract: Kidney stone disease is a multifactorial condition influenced by both genetic predispositionand environmental factors such as lifestyle and dietary habits. Although different monogenic polymorphismshave been proposed as playing a causal role for calcium nephrolithiasis, the prevalenceof these mutations in the general population and their complete pathogenetic pathway is yet tobe determined. General dietary advice … Leggi tutto

ABC’s of medical management of STONES.

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‘Bad dietary habits’ and recurrent calcium oxalate nephrolithiasis

Case report: A 32-year-old truck driver had previously been treated with allopurinol because of hyperuricaemia and gouty =Protein consumption (g/day) arthritis. After having first formed a kidney stone at (adapted from [5]); age 20, he had passed calculi annually for 8 years before he finally underwent ESWL for bilateral radio- it amounted to 108.1 g … Leggi tutto

Iter diagnostico e terapia della calcolosi

La nefrolitiasi è una malattia diffusa nella popolazione generale con una prevalenza in aumento negli ultimi anni. La sua rilevanza clinica è gravata dalla tendenza a recidivare comportando così un rischio aggiuntivo di complicanze sia renali (fino alla malattia renale cronica) che extrarenali (come la malattia metabolica dell’osso). D’altra parte l’inquadramento clinico della malattia può … Leggi tutto

DASH-Style Diet and 24-Hour Urine Composition

Background and objectives: We previously observed associations between a Dietary Approaches to Stop Hypertension (DASH)-style diet and large reductions in kidney stone risk. This study examined associations between a DASH-style diet and 24-hour excretions of urinary lithogenic factors. Conclusions: A DASH-style diet may reduce stone risk by increasing urinary citrate and volume. The small associations … Leggi tutto

Which Diet for Calcium Stone Patients: A Real-World Approach to Preventive Care

 The aim of this review is to give patient-tailored dietary suggestions whatever the level of clinical and biochemistry evaluation. This can help to deliver a useful recommendation, while avoiding excessive dietary restrictions especially when they are not based on a specific diagnosis, and therefore potentially useless or even harmful. We focused our attention on calcium … Leggi tutto