Empagliflozin Changes Urine Supersaturation by Decreasing pH and Increasing Citrate

… This post hoc analysis shows that SGLT2i may reduce kidney calciumcontaining stone risk by decreasing the RSR of CaP minerals in healthy subjects. This effect seems to be mediated by increased urinary citrate and reduced urinary pH. Prospective trials with kidney stone formers are needed to evaluate the effect of SGLT2i in secondary prevention of nephrolithiasis. 

Iter diagnostico e terapia della calcolosi

La nefrolitiasi è una malattia diffusa nella popolazione generale con una prevalenza in aumento negli ultimi anni. La sua rilevanza clinica è gravata dalla tendenza a recidivare comportando così un rischio aggiuntivo di complicanze sia renali (fino alla malattia renale cronica) che extrarenali (come la malattia metabolica dell’osso). D’altra parte l’inquadramento clinico della malattia può … Leggi tutto

Genetic Hypercalciuria

Hypercalciuria is an important, identifiable, and reversible risk factor in stone formation. The foremost and most fundamental step in dissecting the genetics of hypercalciuria is understanding its pathophysiology. Hypercalciuria is a complex trait. This article outlines the various factors that compromise the attempt to dissect the genetics of hypercalciuria, summarizes the clinical and experimental monogenic … Leggi tutto

2 – Nephrocalcinosis and urolithiasis in children Kidney International (2012) 82, 493–497; doi:10.1038/ki.2012.142

Correction to: Kidney International (2011) 80:1278–1291; doi:10.1038/ki.2011.336 In the above-cited article, Table 2 was published with incorrect alignment of age ranges and erroneous unit changes concerning the cystine and urate excretion levels. The urate gram units needed to be multiplied by 10. In Table 1, the diagnosis related to NPT2a mutations should read ‘Urolithiasis, osteoporosis, … Leggi tutto

DASH-Style Diet and 24-Hour Urine Composition

Background and objectives: We previously observed associations between a Dietary Approaches to Stop Hypertension (DASH)-style diet and large reductions in kidney stone risk. This study examined associations between a DASH-style diet and 24-hour excretions of urinary lithogenic factors. Conclusions: A DASH-style diet may reduce stone risk by increasing urinary citrate and volume. The small associations … Leggi tutto

Community Water Quality Linked to Kidney Stones

Although the correlation between water quality and the incidence of kidney stones has been known for some time, only a handful of studies have looked at the association between these two variables Using water-quality reports issued by the California State Water Resources Control Board from 2009 to 2012, which cover 90% of the population supplied … Leggi tutto