Altered Serum Uric Acid Levels in Kidney Disorders

Serum uric acid levels are altered by kidney disorders because the kidneys play a dominant role in uric acid excretion. Here, major kidney disorders which accompany hyperuricemia or hypouricemia, including their pathophysiology, are discussed. Chronic kidney disease (CKD) and hyperuricemia are frequently associated, but recent clinical trials have not supported the pathogenic roles of hyperuricemia … Leggi tutto

Genetic Hypercalciuria

Hypercalciuria is an important, identifiable, and reversible risk factor in stone formation. The foremost and most fundamental step in dissecting the genetics of hypercalciuria is understanding its pathophysiology. Hypercalciuria is a complex trait. This article outlines the various factors that compromise the attempt to dissect the genetics of hypercalciuria, summarizes the clinical and experimental monogenic … Leggi tutto

Progressive chronic kidney disease secondary to tubulointerstitial nephritis in primary biliary cirrhosis

Primary biliary cirrhosis (PBC) is an autoimmune disease characterized by the presence of anti-mitochondrial antibodies (AMA). Whilst asymptomatic distal tubular acidosis (DTA) is the commonest renal lesion reported in PBC, tubulointerstitial nephritis (TIN) has also been reported as a rare association. Although PBC could be a familial disorder, there have been no previous reports of … Leggi tutto

IgM-Positive Tubulointerstitial Nephritis Associated With Asymptomatic Primary Biliary Cirrhosis

Tubulointerstitial nephritis (TIN) is an inflammatory disorder in renal tubules and interstitium without the involvement of glomerular lesions.1TIN is often induced by drugs and infections, but idiopathic or systemic diseaserelated forms have also been observed. Primary biliary cirrhosis (PBC) is an immunemediated chronic and progressive cholestatic liver disease. Laboratory data show increased serum values of … Leggi tutto