eziologia

Evidence for epistatic interaction between VDR and SLC13A2 genes in the pathogenesis of hypocitraturia in recurrent calcium oxalate stone formers

enetic factors play a key role in the pathogenesis of hypocitraturia, a common risk factor for nephrolithiasis. The Na+-dicarboxylate cotransporter NaDC1, encoded by the sodium-dicarboxylate cotransporter (SLC13A2) gene, is a major determinant of urinary citrate excretion and its biological functions are regulated also by the vitamin D/Vitamin D receptor (VDR) biological system. The aim of … Leggi tutto

A Perspective on the Metabolic Potential for Microbial Contributions to Urolithiasis

the diet, host metabolism, and microbial metabolism. The microbial contribution to these compounds is perhaps the most variable given the immense diversity and interindividual variability of microbes inhabiting hosts (microbiome) and the plasticity of host associated microbial communities over time. Recent analyses have found significant associations between antibiotic use and the onset of urolithiasis  as … Leggi tutto

PERCORSO CLINICO ASSISTENZIALE PER LA DIAGNOSI E LA CURA DELLA NEFROLITIASI RECIDIVANTE NELLA AUSLTC

La gestione della nefrolitiasi e soprattutto la gestione delle forme recidivanti di nefrolitiasi necessita dell’intervento e della collaborazione di diverse figure professionali che intervengono nelle diverse fasi della malattia. 0 La mission del nefrologo che è chiamato a comprendere il momento eziopatogenetico della patologia e a mettere in campo tutto quanto ha in se il germe … Leggi tutto