Type 2 diabetes (T2D) is associated with an increased risk of kidney stones. Sodium-glucose cotransporter 2 inhibitors (SGLT2is) might lower the risk of nephrolithiasis by altering urine composition. However, no studies have investigated the association between SGLT2i use and nephrolithiasis risk in patients receiving routine care in the US. After 1:1 propensity score matching, a … Leggi tutto
… This post hoc analysis shows that SGLT2i may reduce kidney calciumcontaining stone risk by decreasing the RSR of CaP minerals in healthy subjects. This effect seems to be mediated by increased urinary citrate and reduced urinary pH. Prospective trials with kidney stone formers are needed to evaluate the effect of SGLT2i in secondary prevention of nephrolithiasis.
… Results We identified 24,290 and 19,576 eligible users of SGLT2Is and GLP1 RAs, respectively. After matching, 12,325 patient pairs remained. The median age was 61 years and median follow-up was 2.0 years. The nephrolithiasis rate was 2.0 per 1000 person-years in SGLT2I initiators compared with 4.0 per 1000 person-years in GLP1 RA initiators, with a rate … Leggi tutto
Diet interventions may reduce the risk of urinary stone formation and its recurrence, but there is no conclusive consensus in the literature regarding the effectiveness of dietary interventions and recommendations about specific diets for patients with urinary calculi. The aim of this study was to review the studies reporting the effects of different dietary interventions … Leggi tutto
ORIGINAL PAPER – SUPPLEMENTARY MATERIALS to the ‘Dietary treatment of urinary risk factors for renal stone formation. A review of CLU Working Group.’ 0
Subjects with idiopathic uric acid nephrolithiasis had lower urine pH (5.5 versus 5.9; P,0.001) andhigher net acid excretion (60 versus 43 mEq/24 h; P,0.001), with the excess H+ carried by nonammoniumbuffers. In all subjects, there was a positive relationship of net acid excretion with higher body mass indexin spite of strictly controlled equivalent dietary acid … Leggi tutto
Higher acid load to the kidney, resulting in higher urinary net acid excretion, is an important factor inthe pathogenesis of idiopathic uric acid nephrolithiasis.Clin J Am Soc Nephrol 14: 411–420, 2019. doi: https://doi.org/10.2215/CJN.10420818 0
A symposium on kidney stones and mineral metabolism held on December 2017 in Brussels, Belgium was the first international multidisciplinary conference of the International Collaborative Network on Kidney Stones and Mineral Metabolism. This meeting addressed epidemiology, underlying pathophysiological mechanisms, genetics, pathological, as well as clinical and research topics. The participants included clinicians and recognized experts … Leggi tutto
Kidney stones are a risk factor for chronic kidney disease (CKD), which, in turn, is a risk factor for myocardial infarction (MI). The objective of this study was to determine whether kidney stones associate with an increased risk for MI. We matched 4564 stone formers (1984 through 2003) on age and gender with 10,860 control … Leggi tutto