A tale of 100 kidney stones
Crohn’s disease with diarrhea predisposes to calcium oxalate stones primarily because of enteric hyperoxaluria from fat malabsorption and saponification resulting in usage of calcium and less formation of insoluble calcium oxalate salts in the intestinal lumen. There is thus increased gastrointestinal oxalate absorption leading to increased urinary oxalate excretion. Other factors include increased oxalate colonic mucosa permeability and gastrointestinal tract decolonization of the … Leggi tutto