Result. We have included a total of 11635698 participants who experienced nephrolithiasis 44 from a total of six clinical studies with nephrolithiasis rates of 1,27% in the SGLT2i group (n 45 = 739197), compared to 1,56% in the control arm (n = 10896501). SGLT-2 inhibitor therapy 46 has been associated with a lower risk for nephrolithiasis compared … Leggi tutto
… A more comprehensive method combining careful morphologic examination of the surface and the section of stones with detailed FTIR analysis of the nature, location, crystalline phases and a respective proportion of stone constituents, therefore termed ‘morphoconstitutional’ analysis, as used in our laboratory for four decades provides more complete etiologic information. In common idiopathic CaOx … Leggi tutto
Crystalluria is a marker of urine supersaturation with substances deriving from metabolic disorders, inherited diseases or drugs. The investigation of crystalluria must be done according to a protocol which includes the delivery to the laboratory of a proper urine sample, the use of a microscope equipped with polarized light, the accurate knowledge of urine pH, … Leggi tutto
The authors hypothesized that glycolic acid derivatives contained in hair-straightening products could be absorbed through the skin and metabolized into oxalate by the liver, thereby leading to calcium oxalate nephropathy 0
Primary hyperoxaluria is a genetic disorder of the metabolism of glyoxylate, the precursor of oxalate. It is characterized by high endogenous production and excessive urinary excretion of oxalate, resulting in the development of calcium oxalate nephrolithiasis, nephrocalcinosis, and, in severe cases, end-stage kidney disease and systemic oxalosis. Three diferent forms of primary hyperoxaluria are currently … Leggi tutto
Estimation of state of saturation with stone-forming salt represents a reliable tool to assess the overall risk. The available methods are based on computer-assisted ab initio calculations. Our earlier method URSUS was subsequently substituted by Lithorisk®, a software including visualization of risk profiles… After digiting input variables (urea and creatinine also included) in a fixed … Leggi tutto
This publication is printed and distributed for educational purposes by MISSION PHARMACAL COMPANY San Antonio, TX 78230-1355 Acknowledgment is made to the following people for expert guidance on the development of this booklet 0 0 0 0
Recent work in nephrolithiasis has benefited from 2 special kinds of imaging: endoscopic study of patient kidneys with high-quality instruments, and examination of stones with microscopic computed tomography (micro CT). The combination of these has provided new evidence that there is more than 1 mechanism by which stones are retained in the kidney until they … Leggi tutto
Diet interventions may reduce the risk of urinary stone formation and its recurrence, but there is no conclusive consensus in the literature regarding the effectiveness of dietary interventions and recommendations about specific diets for patients with urinary calculi. The aim of this study was to review the studies reporting the effects of different dietary interventions … Leggi tutto
Kidney stone disease is an increasingly prevalent condition with remarkable clinical heterogeneity, with regards to stone composition, age of manifestation, rate of recurrence, and impairment of kidney function. Calcium-based kidney stones account for the vast majority of cases, but their etiology is poorly understood, notably their genetic drivers. As recent studies indicate, hereditary conditions are … Leggi tutto