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LITHORISK.COM: the novel version of a software for calculating and visualizing the risk of renal stone

Estimation of state of saturation with stone-forming salt represents a reliable tool to assess the overall risk. The available methods are based on computer-assisted ab initio calculations. Our earlier method URSUS was subsequently substituted by Lithorisk®, a software including visualization of risk profiles…  After digiting input variables (urea and creatinine also included) in a fixed … Leggi tutto

ABC’s of medical management of STONES.

This publication is printed and distributed  for educational purposes by  MISSION PHARMACAL COMPANY  San Antonio, TX 78230-1355 Acknowledgment is made to  the following people for expert guidance  on the development of this booklet 0 0 0 0

Retention and growth of urinary stones: insights from imaging

Recent work in nephrolithiasis has benefited from 2 special kinds of imaging: endoscopic study of patient kidneys with high-quality instruments, and examination of stones with microscopic computed tomography (micro CT). The combination of these has provided new evidence that there is more than 1 mechanism by which stones are retained in the kidney until they … Leggi tutto

Update on Hereditary Kidney Stone Disease and Introduction of a New Clinical Patient Registry in Germany

Kidney stone disease is an increasingly prevalent condition with remarkable clinical heterogeneity, with regards to stone composition, age of manifestation, rate of recurrence, and impairment of kidney function. Calcium-based kidney stones account for the vast majority of cases, but their etiology is poorly understood, notably their genetic drivers. As recent studies indicate, hereditary conditions are … Leggi tutto

Gestione dell’Iperossaluria Primitiva tipo 1 in Italia

L’iperossaluria primitiva tipo 1 è una malattia genetica rara; l’esordio dei sintomi varia dall’infanzia alla sesta decade di vita e la malattia può non essere riconosciuta per diversi anni. C’è la necessità di farmaci in grado di inibire la produzione epatica di ossalato e di prevenire la progressione della malattia; uno dei farmaci più promettenti … Leggi tutto

Caratterizzazione dei calcoli urinari mediante spettroscopia Raman e spettroscopia infrarossa in trasformata di Fourier a confronto col metodo chimico-colorimetrico

Chemical-colorimetric methods for kidney stones identification are widely adopted in most routine laboratories due to low cost with no need of instrumental analysis. Actually, kidney stones are well characterized with the Fourier transform infrared spectroscopy combined with Attenuated Total Reflection (ATR/FT-IR) that allows quick identification of chemical compounds into solid samples. Furthermore, Raman spectroscopy is … Leggi tutto

Perspectives in primary hyperoxaluria — historical, current and future clinical interventions

Primary hyperoxalurias are a devastating family of diseases leading to multisystem oxalate deposition, nephrolithiasis, nephrocalcinosis and end-stage renal disease. Traditional treatment paradigms are limited to conservative management, dialysis and combined transplantation of the kidney and liver, of which the liver is the primary source of oxalate production. However, transplantation is associated with many potential complications, … Leggi tutto