Empagliflozin Changes Urine Supersaturation by Decreasing pH and Increasing Citrate

… This post hoc analysis shows that SGLT2i may reduce kidney calciumcontaining stone risk by decreasing the RSR of CaP minerals in healthy subjects. This effect seems to be mediated by increased urinary citrate and reduced urinary pH. Prospective trials with kidney stone formers are needed to evaluate the effect of SGLT2i in secondary prevention of nephrolithiasis. 

Sodium–glucose cotransporter 2 inhibitors and risk of nephrolithiasis

…  Results We identified 24,290 and 19,576 eligible users of SGLT2Is and GLP1 RAs, respectively. After matching, 12,325 patient pairs remained. The median age was 61 years and median follow-up was 2.0 years. The nephrolithiasis rate was 2.0 per 1000 person-years in SGLT2I initiators compared with 4.0 per 1000 person-years in GLP1 RA initiators, with a rate … Leggi tutto

Kidney Stones, Proteinuria and Renal Tubular Metabolic Acidosis: What Is the Link?

Kidney stone disease represents a rare cause of chronic kidney disease (2–3%) but has severe clinical consequences. Type 1 renal tubular acidosis is a strong lithogenic condition mainly related to primary Sjögren syndrome. This study aimed to illustrate an unusual presentation of Sjögren syndrome to improve the knowledge about rare kidney stone diseases, and to … Leggi tutto

Distal renal tubular acidosis: ERKNet/ESPN clinical practice points

Distal renal tubular acidosis (dRTA) is characterized by an impaired ability of the distal tubule to excrete acid, leading to metabolic acidosis. Associated complications include bone disease, growth failure, urolithiasis and hypokalaemia. Due to its rarity, there is limited evidence to guide diagnosis and management; however, available data strongly suggest that metabolic control of the … Leggi tutto

Deficit di adenina fosforibosiltransferasi (APRT) 2,8-diidrossiadenina (2,8- DHA)

 deficit di adenina fosforibosiltransferasi (APRT) è una malattia rara autosomica recessiva, con formazione di 2,8-diidrossiadenina (2,8- DHA)  e sua eliminazione nelle urine con conseguenti urolitiasi e nefropatia da deposito di cristalli sino alla IRC. La prevalenza è di 1/50.000-1/100.000 nelle popolazioni caucasiche. 0 0 0

IgM-Positive Tubulointerstitial Nephritis Associated With Asymptomatic Primary Biliary Cirrhosis

Tubulointerstitial nephritis (TIN) is an inflammatory disorder in renal tubules and interstitium without the involvement of glomerular lesions.1TIN is often induced by drugs and infections, but idiopathic or systemic diseaserelated forms have also been observed. Primary biliary cirrhosis (PBC) is an immunemediated chronic and progressive cholestatic liver disease. Laboratory data show increased serum values of … Leggi tutto

IgM-Positive Plasma Cell-Tubulointerstitial Nephritis

Infiltration by IgG-positive plasma cells is a common finding in tubulointerstitial nephritis. Indeed, it has been thought that CD138-positive mature plasma cells secrete mainly IgG, and the occurrence of tubulointerstitial nephritis with CD138-positive plasma cells secreting IgM has rarely been reported.  The clinical findings for these patients included a high prevalence of distal renal tubular acidosis … Leggi tutto

Sindrome di Bartter, grave patologia renale rara orfana di farmaci: un passo avanti verso la terapia mediante studi farmacogenetici ed epidemiologici

Le sindromi di Bartter (BS tipo 1-5) rappresentano un gruppo di tubulopatie renali rare a carattere autosomico recessivo che si manifestano con fenotipi clinici parzialmente sovrapponibili caratterizzati da perdita di sali, alcalosi metabolica, ipokaliemica, poliuria, polidipsia, debolezza muscolare e ritardo della crescita. Tali patologie sono dovute a un difetto nel riassorbimento dello ione sodio, potassio … Leggi tutto

Meeting report of the “Symposium on kidney stones and mineral metabolism: calcium kidney stones in 2017”

A symposium on kidney stones and mineral metabolism held on December 2017 in Brussels, Belgium was the first international multidisciplinary conference of the International Collaborative Network on Kidney Stones and Mineral Metabolism. This meeting addressed epidemiology, underlying pathophysiological mechanisms, genetics, pathological, as well as clinical and research topics. The participants included clinicians and recognized experts … Leggi tutto

Kidney Stones Associate with Increased Risk for Myocardial Infarction

Kidney stones are a risk factor for chronic kidney disease (CKD), which, in turn, is a risk factor for myocardial infarction (MI). The objective of this study was to determine whether kidney stones associate with an increased risk for MI. We matched 4564 stone formers (1984 through 2003) on age and gender with 10,860 control … Leggi tutto