Management of de novo nephrolithiasis after kidney transplantation: a comprehensive review from the European Renal Association CKD-MBD working group

The lifetime incidence of kidney stones is 6%–12% in the general population. Nephrolithiasis is a known cause of acute and chronic kidney injury, mediated via obstructive uropathy or crystal-induced nephropathy, and several modifiable and non-modifiable genetic and lifestyle causes have been described. Evidence for epidemiology and management of nephrolithiasis after kidney transplantation is limited by … Leggi tutto

Comprehensive morpho-constitutional analysis of urinary stones improves etiological diagnosis and therapeutic strategy of nephrolithiasis

… A more comprehensive method combining careful morphologic examination of the surface and the section of stones with detailed FTIR analysis of the nature, location, crystalline phases and a respective proportion of stone constituents, therefore termed ‘morphoconstitutional’ analysis, as used in our laboratory for four decades provides more complete etiologic information. In common idiopathic CaOx … Leggi tutto

A tale of 100 kidney stones

Crohn’s disease with diarrhea predisposes to calcium oxalate stones primarily because of enteric hyperoxaluria from fat malabsorption and saponification resulting in usage of calcium and less formation of insoluble calcium oxalate salts in the intestinal lumen. There is thus increased gastrointestinal oxalate absorption leading to increased urinary oxalate excretion. Other factors include increased oxalate colonic mucosa permeability and gastrointestinal tract decolonization of the … Leggi tutto

Lumasiran, Isolated Kidney Transplantation, and Continued Vigilance

Patient 1, a girl with infantile oxalosis, was homozygous for c.731T→C (of unclear predicted pyridoxine sensitivity). She underwent intensive dialysis for 10 months before the initiation of lumasiran treatment, followed by 13 months of intensive dialysis plus lumasiran. At 3 years of age, she underwent isolated kidney transplantation from a deceased donor; the plasma oxalate level at the … Leggi tutto

The Acute and Long-Term Adverse Effects of Shock Wave Lithotripsy

Shock wave lithotripsy (SWL) has proven to be a highly effective treatment for the removal of kidney stones. Shock waves (SWs) can be used to break most stone types, and because lithotripsy is the only noninvasive treatment for urinary stones, SWL is particularly attractive. On the downside SWL can cause vascular trauma to the kidney … Leggi tutto

A lavatory urine color (LUC) chart method can identify hypohydration in a physically active population

To provide a new and efcient at-the-toilet-bowl method of self-assessing urine concentration via urine color (Uc) to identify hypohydration. … Urine color was scored similarly by subjects and investigators (P=0.99). Based on receiver operating curves (ROC), the method scored fair, i.e., the area under the curve ranging 0.73–0.82, with an accuracy of participants and investigators … Leggi tutto

EAU guidelines on nephrolithiasis 2’23

The European Association of Urology (EAU) Urolithiasis Guidelines Panel has prepared these guidelines to help urologists assess evidence-based management of stones/calculi in the urinary tract and incorporate recommendations into clinical practice. This document covers most aspects of the disease, which is still a cause of significant morbidity despite technological and scientific advances. The Panel is … Leggi tutto