IgM-Positive Tubulointerstitial Nephritis Associated With Asymptomatic Primary Biliary Cirrhosis

Tubulointerstitial nephritis (TIN) is an inflammatory disorder in renal tubules and interstitium without the involvement of glomerular lesions.1TIN is often induced by drugs and infections, but idiopathic or systemic diseaserelated forms have also been observed. Primary biliary cirrhosis (PBC) is an immunemediated chronic and progressive cholestatic liver disease. Laboratory data show increased serum values of alkaline phosphatase, g-glutamyl transpeptidase, and IgM. The hallmark of the disease is the circulating antimitochondrial antibody (AMA). PBC is often associated with extrahepatic autoimmune disorders, such as Sjögren syndrome, thyroid disorders, systemic sclerosis, and rheumatoid arthritis.


AUTORE: Shoko Mizoguchi et al